W. Du

This paper describes ensovibep, a trispecific DARPin that inhibits SARS-CoV-2 variants by targeting the spike protein, showing potent antiviral activity and protection in animal models.

This study investigates how H3K9 acetylation modification affects TLR9 expression and immune response in patients treated with thymosin a1 and entecavir for hepatitis B.

This paper develops potent anti-SARS-CoV-2 DARPin therapeutics with low picomolar neutralization efficacy and reports their protective efficacy in a hamster model.

This study identifies AXL as a key driver of cell plasticity and metastasis in pancreatic cancer using single-cell RNA sequencing and mouse models.

The paper investigates the antagonistic epistasis between Hnf4a and FoxO1 networks in beta-cell function through enhancer interactions and gene expression analysis.

This study reconstructs the three-dimensional vasculature of Anaxagorea carpels, finding a radiosymmetrical pattern consistent with the Unifying Theory of carpel origin.

The paper shows that tissue-resident memory CD4+ T cells mobilize into the blood after vaccination and contribute to systemic secondary immune responses.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

This study shows NatB regulates Rb mutant cell survival and tumor growth by modulating EGFR/MAPK signaling through N-end rule pathways by affecting protein stability.

This study uses single-cell RNA sequencing to analyze cellular heterogeneity in mouse pancreatic ductal adenocarcinoma progression, identifying epithelial-to-mesenchymal transition, inflammatory macrophages, and fibroblast subtypes.

This study identifies TBK1 as a key driver of epithelial plasticity in KRAS-mutant pancreatic cancer, showing its role in tumor growth and metastasis through Axl-mediated activation.