Author

L. S. Wicker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:flow cytometry· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. A. Todd· 3 shared M. L. Pekalski· 3 shared A. J. Cutler· 2 shared A. Rubio Garcia· 2 shared C. Wallace· 2 shared D. B. Dunger· 2 shared D. B. Rainbow· 2 shared D. J. Smyth· 2 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

J. A. Todd

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Author profile →

4 papers

Recent·Most cited

Hiding in Plain Sight: Thymic CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissues

L. B. Jarvis, S. K. Howlett, D. Rainbow, V. Coppard, R. Ferreira, E. Needham, A. Prabhu, S. Alkwai, L. Ellis, Z. Georgieva, O. Suchanek, H. S. Mousa, K. T. Mahbubani, K. Saeb-Parsy, L. S. Wicker, J. L. Jones

The paper identifies CD8+FOXP3+ Tregs enriched in human tissues, expressing intracellular CD25 and tissue residency markers, and demonstrates their therapeutic potential and association with disease states.

bioRxiv · Dec 24, 2023 · PreprintImmunology

Peripheral tolerance to insulin is encoded by mimicry in the microbiome

A. Rubio Garcia, A. Paterou, M. Lee, H. Slawinski, L. S. Wicker, J. A. Todd, M. L. Pekalski

The paper identifies microbial mimicry of insulin epitopes in the gut microbiome as a potential cause of type 1 diabetes by showing that transketolase mimotopes trigger immune responses similar to insulin.

bioRxiv · Dec 18, 2019 · PreprintImmunology

Cells With Treg-Specific FOXP3 Demethylation But Low CD25 Are Prevalent In Autoimmunity

R. C. Ferreira, H. Z. Simons, W. Thompson, D. B. Rainbow, X. Yang, A. J. Cutler, J. Oliveira, X. C. Dopico, D. J. Smyth, N. Savinykh, M. Mashar, T. Vyse, D. B. Dunger, H. Baxendale, A. Chandra, , M. L. Pekalski

The paper identifies CD25lowFOXP3+ T cells as a subset of regulatory T cells expanded in autoimmune diseases, characterized by FOXP3 demethylation and distinct functional features.

bioRxiv · May 5, 2017Immunology

Recent thymic emigrants produce antimicrobial IL-8, express complement receptors and are precursors of a tissue-homing Th8 lineage of memory cells

M. L. Pekalski, A. Rubio Garcia, R. C. Ferreira, D. B. Rainbow, D. J. Smyth, M. Mashar, J. Brady, N. Savinykh, X. Castro Dopico, S. Mahmood, S. Duley, H. E. Stevens, N. M. Walker, A. J. Cutler, F. Waldron-Lynch, , L. S. Wicker

The paper identifies CR2+ naive T cells as recent thymic emigrants that express antimicrobial IL-8 and complement receptors, and may become tissue-homing memory cells.

bioRxiv · Jun 17, 2016Immunology