X. Tang

This paper introduces a deep learning method for single-frame super-resolution microscopy, enabling live-cell imaging at nanometer-scale spatial and millisecond temporal resolutions.

This study identifies a tick metabolic pathway involving ISARL that Borrelia burgdorferi exploits to establish infection, suggesting a mechanism for manipulating host metabolism.

This study shows LRP-1 supports tumour cell motility under ischemic conditions by coordinating two distinct signalling pathways involving Hsp90 and EGFR.

This paper introduces an integrated system for automated multi-functional imaging and analysis to study YAP mechanosensitivity in human cells.

This study identifies genomic changes and novel toxins in Liberibacter pathogens through comparative phylogenomic analysis, linking prophage loci and gene gains/losses to pathogenicity.

AMFIP enables automatic multi-functional live-cell imaging by integrating hardware and software without extra costs or hardware, demonstrating its utility in mechanobiology studies.

The paper designs chimeric antisense oligonucleotides that degrade SARS-CoV-2 RNA via RNase L activation, showing twice the efficiency of classic antisense oligonucleotides and broad-spectrum antiviral activity.

This study identifies intrinsic cardiac adrenergic cells as contributors to septic cardiomyopathy by releasing norepinephrine that exacerbates cardiac dysfunction through β1-adrenergic receptor activation.

This paper identifies a novel repair mechanism in cartilage where aggrecan-dependent sodium flux, triggered by mechanical injury, releases growth factors that promote tissue regeneration, which is impaired in osteoarthritis.

This study evaluates how SARS-CoV-2 variants bind animal ACE2 proteins and their sensitivity to neutralizing antibodies and ACE2-Ig constructs, finding increased ACE2 affinity and partial resistance to antibodies but enhanced neutralization by ACE2-Ig.

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

This study develops and characterizes high-affinity mouse monoclonal antibodies against SARS-CoV-2, showing their neutralizing and diagnostic potential.

This study identifies exosomal lncRNA PICALM-AU1 from cholangiocytes as a key regulator of endothelial-mesenchymal transition in hepatopulmonary syndrome, with potential as a biomarker and therapeutic target.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

The paper identifies NRS1, a nitrogen-responsive microprotein in budding yeast, that provides an alternative mechanism for G1/S transcriptional activation under poor nitrogen conditions.

The paper investigates the host range of SARS-CoV-2 and related coronaviruses and identifies an improved ACE2-Fc variant effective against both SARS-CoV-2 and SARS-CoV-1.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

The paper shows that commensal microbes up-regulate host transferrin to suppress TLR signaling and promote immune tolerance in the gut.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

This study identifies a biosynthetic pathway in Streptococcus mutans that produces strain-specific antibiotics, which inhibit commensal bacteria and contribute to dental caries.

This study compares anaerobic microbial communities involved in dechlorinating different HCH isomers, identifying key bacteria and revealing shifts in community composition based on substrate.

The paper shows that iron-deficiency and estrogen increase transferrin, leading to hypercoagulability and worsened ischemic stroke.