X. Ye

This study identifies MTHFD2 as a metabolic checkpoint that regulates T cell fate and function by promoting effector cells and suppressing regulatory T cells.

This study examines how parasitaemia levels during Plasmodium yoelii infection in mice affect intestinal microbiota composition and correlate with immune cell development.

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

This paper identifies high-affinity peptide binders for the SARS-CoV-2 spike protein using affinity selection-mass spectrometry, with nanomolar affinities and selectivity over human serum proteins.

The paper uses intravital imaging to show macrophage-induced cancer stem cells (CSCs) are enriched at TMEM doorways during metastasis, with CSCs comprising >60% of circulating tumor cells.

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

This study introduces a method to measure RNA-protein binding kinetics in cells and shows that Dazl binds RNA sites briefly but influences mRNA levels through clustered binding.

This study establishes a relative adrenal insufficiency (RAI) animal model and shows that glucocorticoid (GC) therapy benefits RAI mice but harms non-RAI mice, supporting a precision medicine approach for sepsis treatment.

The paper analyzes carbon, nitrogen, and phosphorus stoichiometric ratios in plant organs and soil of four wetland plant communities to understand nutrient dynamics and environmental influences.

This study assesses the antioxidant, antimicrobial, and cytotoxic properties of ultrasound-assisted acetone extracts from Plectranthus amboinicus.

The paper identifies CREBBP dependency in a DLBCL cell line with EP300 truncation using CRISPR-Cas9 screens and genomic data, suggesting therapeutic targets for heterogeneous cancers.

The paper compares subgenome asymmetry in artificial and natural allopolyploid genotypes, finding that variable genome components influence subgenome differences and suggest their consideration in polyploid evolution studies.

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

The paper shows ancestral subdivision can falsely signal homoploid hybridization in wheat's D lineage, challenging the belief that hybridization contributed to its origin.

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

The paper develops a stochastic model to explain how molecular chaperones maximize native state production rates by driving substrates out of equilibrium, reconciling conflicting experimental results on ribozyme and protein folding.