Author

Z. Weng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 2 Biophysics· 1 Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:drug response / drug discovery· 4 Assay:whole-genome sequencing· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:electrophysiology· 2

Frequent Co-Authors

H. Li· 2 shared H. Sun· 2 shared A. Blackford· 1 shared A. Chen· 1 shared A. Eisenberg· 1 shared A. Henssen· 1 shared A. Kentsis· 1 shared A. Lal· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBioengineering

H. Li

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Long-Term In Vivo Molecular Monitoring Using Aptamer-Graphene Microtransistors

G. Wu, E. T. Zhang, Y. Qiang, C. Esmonde, X. Chen, Z. Wei, Y. Song, X. Zhang, M. J. Schneider, H. Li, H. Sun, Z. Weng, S. Santaniello, J. He, R. Y. Lai, , Y. Zhang

This paper introduces AGMs for long-term in vivo molecular monitoring, demonstrating detection of dopamine and serotonin in blood and in vivo dopamine release in mice for over a week.

bioRxiv · Oct 18, 2023 · PreprintBioengineering

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

Y. Ou, M. Liu, K. Zhan, W. Wu, J. Huang, H. Sun, H. Zheng, X. Yu, H. Gong, Z. Han, A. Chen, Y. Liao, Y. Lin, G. Liu, Q. Liu, , S. Zhong

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

bioRxiv · Oct 12, 2022 · PreprintImmunology

Structural and mechanistic insights into the MCM8/9 helicase complex

Z. Weng, J. Zheng, Y. Zhou, Z. Lu, Y. Wu, D. Xu, H. Li, H. Liang, Y. Liu

This study reports the structure of the MCM8/9 helicase complex using cryo-EM, revealing its DNA unwinding mechanism through conformational changes and rotary motions.

bioRxiv · Jan 26, 2022Biophysics

GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance

W. Chen, J. S. Brown, T. He, W.-S. Wu, S. Tu, Z. Weng, D. Zhang, H.-C. Lee

This study shows that GLH/VASA helicases are essential for forming germ granules, which ensure accurate piRNA-mediated transcriptome surveillance by distinguishing self from non-self.

bioRxiv · Jan 21, 2022Cell Biology

Regulation of the PKD2 channel function by TACAN

X. Liu, R. Zhang, M. Fatehi, Y. Wang, W. Long, R. Tian, X. Deng, Z. Weng, Q. Xu, P. E. Light, J. Tang, X.-Z. Chen

This study identifies TACAN as a PKD2 inhibitor that modulates its channel activity and mechano sensitivity in renal cells and zebrafish.

bioRxiv · Dec 23, 2021Physiology

Ex Vivo Culture Models of Hidradenitis Suppurativa for defining molecular pathogenesis and treatment efficacy of novel drugs

K. Goliwas, M. P. Kashyap, J. Khan, R. Sinha, Z. Weng, A. S. Oak, L. Jin, V. Attigadda, M. B. Lee, C. A. Elmets, M. S. Mukhtar, J. S. Deshane, M. Athar

This paper develops three ex vivo skin culture models for HS to study molecular pathogenesis and drug efficacy.

bioRxiv · Oct 11, 2021Pathology

Programming large target genomic deletion and concurrent insertion via a prime editing-based method: PEDAR

T. Jiang, X.-O. Zhang, Z. Weng, W. Xue

The paper introduces PEDAR, a prime editing method that deletes and repairs genomic insertions, restoring gene function in a mouse model.

bioRxiv · May 12, 2021 · PreprintBioengineering

Comprehensive Genomic Characterization of Breast Tumors with BRCA1 and BRCA2 Mutations

A. Lal, D. Ramazzotti, Z. Weng, K. Liu, J. Ford, A. Sidow

This study compares genomic features of BRCA1/BRCA2-mutated breast tumors with sporadic tumors, finding differences in mutation patterns, DNA methylation, and structural variation.

bioRxiv · May 19, 2019Cancer Biology

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors

A. Henssen, R. Koche, J. Zhuang, E. Jiang, C. Reed, A. Eisenberg, E. Still, I. MacArthur, E. Rodriguez-Fos, S. Gonzalez, M. Puiggros, A. Blackford, C. Mason, E. De Stanchina, M. Gonen, , A. Kentsis

This study identifies PGBD5 as an oncogenic DNA transposase in rhabdoid tumors, causing site-specific genomic rearrangements through PSS sequences and end-joining repair.

bioRxiv · Feb 23, 2017Cancer Biology