T. Miyamoto

Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy

This study introduces ExAPC microscopy for label-free visualization of intracellular structures, showing its ability to resolve biomolecular condensates, lipid droplets, and mitochondria with high spatiotemporal resolution.

Inhibition of OCT4 Binding at the MYCN Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

This study shows that inhibiting OCT4 binding at the MYCN locus in neuroblastoma cells reduces MYCN activity, leading to cell death through caspase-2 activation and downregulation of high-ORF dominance transcripts.

Activity-dependent glassy cell mechanics : Mechanical properties measured with active microrheology

This study measures mechanical properties of living cells using active microrheology and finds that cell mechanics are governed by glassy cytoplasm, with ATP depletion leading to solidification and metabolic activity promoting fluid-like behavior.

AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewings sarcoma cells

The paper identifies AHDC1 as a protein interacting with EWS-FLI1 in Ewing's sarcoma and shows its knockdown reduces cell growth and transcriptional activity.

Multi-compartment tumor organoids

This paper develops a high-throughput microtechnology to create multi-compartment tumor organoids that mimic tumor microenvironments and improve drug response and tumor progression studies.

A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of Diffuse Large B-cell Lymphoma

The paper identifies a germinal center-associated microenvironmental signature in DLBCL that correlates with prognosis and molecular features, showing its impact on clinical outcomes.

Synthetic peptide-induced internalization of biomolecules into various plant and algal cells via micropinocytosis

The paper introduces a peptide-based method for delivering biomolecules into plant and algal cells via micropinocytosis, enabling efficient and high-throughput delivery of functional cargoes.