Author

K. Nakatani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

H. Kogashi· 3 shared Y. Suenaga· 3 shared K. Kugou· 2 shared M. Kato· 2 shared Y. Hasegawa· 2 shared Y. Hippo· 2 shared A. Vandenbon· 1 shared C. He· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

H. Kogashi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Low albumin status accompanies multi-layered immunosuppressive phenotypes in metastatic breast cancer patients

Y. Nakamura, M. Yoda, Y. Izumi, Y. Kashima, M. Takahashi, K. Nakatani, T. Bamba, C. He, R. Konishi, D. P. Saldajeno, A. Vandenbon, Y. Suzuki, M. Toi, K. Kawaguchi, S. Kawaoka

The paper investigates the association between low albumin levels and immunosuppressive phenotypes in metastatic breast cancer patients using transcriptomic and metabolomic data.

bioRxiv · Sep 5, 2023 · PreprintCancer Biology

Inhibition of OCT4 Binding at the MYCN Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

K. Nakatani, H. Kogashi, T. Miyamoto, T. Setoguchi, T. Sakuma, K. Kugou, Y. Hasegawa, T. Yamamoto, Y. Hippo, Y. Suenaga

This study shows that inhibiting OCT4 binding at the MYCN locus in neuroblastoma cells reduces MYCN activity, leading to cell death through caspase-2 activation and downregulation of high-ORF dominance transcripts.

bioRxiv · Jun 8, 2023 · PreprintCancer Biology

Global changes in open reading frame dominance of RNAs during cancer initiation and progression

Y. Suenaga, H. Kogashi, K. Nakatani, J. Lin, Y. Hasegawa, K. Kugou, Y. Kawashima, E. Furukawa, K. Okumura, E. Kita, Y. Wakabayashi, M. Kato, M. Kawazu, Y. Hippo

The paper measures ORF dominance in cancer and finds it increases with carcinogenesis, correlates with translation, and blurs coding/noncoding boundaries before metastasis.

bioRxiv · Jun 2, 2023 · PreprintCancer Biology

Protein-coding potential of RNAs measured by potentially translated island scores

Y. Suenaga, M. Kato, M. Nagai, K. Nakatani, H. Kogashi, M. Kobatake, T. Makino

This study introduces a PTI score to measure RNA coding potential and finds it correlates with translation and overlaps between coding and noncoding RNAs in different species.

bioRxiv · Apr 14, 2021Evolutionary Biology

Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model

T. Shibata, K. Nagano, M. Ueyama, K. Ninomiya, H. Tetsuro, Y. Nagai, K. Ishikawa, G. Kawai, K. Nakatani

This paper identifies a small molecule that targets toxic RNA repeats in a Drosophila model of SCA31, reducing RNA foci and alleviating disease symptoms.

bioRxiv · Oct 5, 2020Biochemistry