Inhibition of the BMP pathway suppresses tumor growth via downregulation of EGFR in MEK/ERK-dependent colorectal cancer
S. Shimizu, J. Kondo, K. Onuma, K. Ota, M. Kamada, Y. Harada, Y. Tanaka, M. Adachi Nakazawa, Y. Tamada, Y. Okuno, K. Kawada, K. Obama, R. J. Coffey, Y. Fujiwara, M. Inoue
This study shows that inhibiting the BMP pathway suppresses colorectal cancer growth by reducing EGFR, and combining BMP and MEK inhibition enhances therapeutic effects in patient-derived organoids.
bioRxiv · Nov 1, 2022 · PreprintCancer Biology