J. Kondo

Inhibition of the BMP pathway suppresses tumor growth via downregulation of EGFR in MEK/ERK-dependent colorectal cancer

This study shows that inhibiting the BMP pathway suppresses colorectal cancer growth by reducing EGFR, and combining BMP and MEK inhibition enhances therapeutic effects in patient-derived organoids.

Hepatocyte Differentiation From Mouse Liver Ductal Organoids By Transducing Four Liver-Specific Transcription Factors

This study identifies four transcription factors that enhance hepatocyte differentiation from liver ductal organoids, improving their functionality and reducing cholangiocyte characteristics.

Distinct and interchangeable growing patterns in colorectal cancer stem-like cells are regulated by Musashi-1

The paper identifies distinct growth patterns in colorectal cancer stem-like cells and shows Musashi-1 regulates their plasticity and drug resistance.

Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts

The paper demonstrates that liver ductal organoids can reconstruct intrahepatic bile ducts in decellularized liver grafts, mimicking native liver structure and function.

Enterococcus spp. have higher fitness for survival, in a pH-dependent manner, in pancreatic juice among duodenal bacterial flora

The paper investigates the survival of Enterococcus faecalis in pancreatic juice under different pH conditions and finds it has higher fitness in alkaline environments.

A survey of vaccine-induced measles IgG antibody titer and the verification of changes in temporal differences of measles vaccination in young adults

This study examines measles IgG antibody titers in young adults and finds that antibody levels correlate with medical history and time since last vaccination, suggesting the need for periodic measles vaccination.