Y. Ye

This paper introduces ldSPIM, a method combining light sheet microscopy with nanopipette delivery to precisely deliver single molecules to cells and image their effects in real-time.

This study shows miR-100-5p reduces prostate cancer cell proliferation, migration, and invasion by downregulating mTOR.

The paper shows that the SUMO system regulates TOC complex stability and chloroplast development in Arabidopsis by stabilizing TOC proteins.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

This meta-analysis evaluates the diagnostic accuracy of RASSF1A promoter methylation in prostate cancer, finding high specificity and area under the ROC curve.

This study shows heparan sulfate aids SARS-CoV-2 entry and identifies drugs that inhibit this process in vitro.

The paper shows HOXB13 expression is reduced or lost in neuroendocrine prostate cancer (NEPCa) and that NEPCa tumors lose prostate-specific HOX codes without gaining a clear new tissue identity.

This study shows filamentous recombinant human Tau activates astrocytes via integrin V/{beta}1 receptor, leading to neurotoxic effects through NF{kappa}B signaling.

This study introduces single-cell entropy (scEntropy) to quantify reprogramming and differentiation dynamics in iPSCs using scRNA-seq data, showing increases during differentiation and decreases during reprogramming.

This study identifies Myosin-7B and SLC35B2 as critical regulators of α-Synuclein fibril endocytosis, revealing a distinct pathway involving HSPG interactions and actin dynamics.

The paper introduces a FRET-based assay to measure ubiquitination kinetics in vitro, demonstrating its versatility and compatibility with various enzyme combinations.

The paper shows that N-terminal ubiquitination of amyloidogenic proteins by UBE2W alters their aggregation process, enabling proteasome targeting of soluble oligomers.

This study examines microbial interactions in asthma airways, finding increased bacterial and fungal diversity and significant associations between Moraxellaceae, Moraxella, and the airway mycobiome.

This study shows the proteasome holoenzyme fragments amyloid fibrils into smaller, more toxic species, suggesting a novel degradation mechanism for filamentous aggregates.

This paper presents the crystal structure of Bag6 and TRC35, revealing how TRC35 regulates Bag6's nucleo-cytoplasmic distribution and prevents its degradation.