Author

Y.-Q. Deng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 4 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Q. Chen· 6 shared X.-F. Li· 5 shared C.-F. Qin· 4 shared Q. Ye· 4 shared X. Wang· 4 shared X. Yang· 4 shared Y. Wang· 4 shared Y. Zhang· 4 shared

Activity by Year

2020-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersMicrobiology

Q. Chen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Competitive fitness and homologous recombination of SARS-CoV-2 variants of concern

C.-F. Qin, Q. Chen, Q. Si, H. Zhou, Y.-Q. Deng, P.-D. Shi, H. Zhao, X.-F. Li, X.-Y. Huang, Y. Wu, Y. Guo, G. Pei, Y. Wang, S.-Q. Sun, Z.-M. Du, , H. Fan

This study examines the competitive fitness and homologous recombination of SARS-CoV-2 variants in vitro, showing cell-specific fitness differences and recombination hotspots.

bioRxiv · Jul 26, 2023Microbiology

Double Lock of a Potent Human Monoclonal Antibody against SARS-CoV-2

X. Wang, C. Qin, Y. Wang, Z. Rao, L. Xie, L. Zhu, Y.-Q. Deng, R.-r. Zhang, Z. Cui, C.-Y. Sun, C.-F. Fan, X. Xing, W. Huang, Q. Chen, N.-N. Zhang, , J. Hu

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

bioRxiv · Nov 24, 2020 · PreprintBiophysics

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

S. Sun, H. Gu, L. Cao, Q. Chen, Q. Ye, G. Yang, R.-T. Li, H. Fan, Y.-Q. Deng, X. Song, Y. Qi, M. Li, J. Lan, R. Feng, G. Yan, , C. Qin

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

bioRxiv · Nov 10, 2020Microbiology

SARS-CoV-2 infection causes transient olfactory dysfunction in mice

C.-F. Qin, Q. Ye, J. Zhou, G. Yang, R.-T. Li, Q. He, Y. Zhang, S.-J. Wu, Q. Chen, J.-H. Shi, R.-R. Zhang, H.-M. Zhu, H.-Y. Qiu, T. Zhang, Y.-Q. Deng, , X. Yang

This study shows SARS-CoV-2 infection causes temporary olfactory dysfunction in mice by targeting olfactory epithelium cells and disrupting their structure and function.

bioRxiv · Nov 10, 2020 · PreprintMicrobiology

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Z. Lv, Y.-Q. Deng, Q. Ye, L. Cao, C.-Y. Sun, C. Fan, W. Huang, S. Sun, Y. Sun, L. Zhu, Q. Chen, N. Wang, J. Nie, Z. Cui, D. Zhu, , X. Wang

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

Science · Sep 18, 2020Peer-reviewedBiophysics

Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

H. Gu, Q. Chen, G. Yang, L. He, H. Fan, Y.-q. Deng, Y. Wang, Y. Teng, Z. Zhao, Y. Cui, Y. Li, X.-F. Li, J. Li, N. Zhang, X. Yang, , Y. Zhou

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

bioRxiv · May 2, 2020 · PreprintMicrobiology

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

K. Wang, W. Chen, Y.-S. Zhou, J.-Q. Lian, Z. Zhang, P. Du, L. Gong, Y. Zhang, H.-Y. Cui, J.-J. Geng, B. Wang, X.-X. Sun, C.-F. Wang, X. Yang, P. Lin, , Z.-N. Chen

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

bioRxiv · Mar 14, 2020Microbiology