Yuxuan Zhang

Fab Dimerization Crosslinks and Activates the γδ T-Cell Receptor

This study presents the structures of the Vγ9Vδ2 TCR in inactive and agonist-crosslinked states, revealing a dimerization-driven activation mechanism.

Unmasking genetic load: Genomic inbreeding drives growth depression in captive critically endangered Chinese Bahaba (Bahaba taipingensis)

The paper investigates genomic inbreeding effects on growth depression in captive Chinese bahaba, identifying genetic factors linked to skeletal and immune pathways.

From pelagic to reef: Genomic basis of morphological adaption during life-history transition in the orbicular batfish (Platax orbicularis)

The paper investigates the genomic basis of metamorphosis in orbicular batfish, identifying gene family expansions and differentially expressed genes involved in developmental reprogramming during life-history transition.

A pan-genomic and methylomic analysis reveals a distinct signature in Vibrio alginolyticus isolated from wild fish

This study analyzes the pan-genome and methylome of Vibrio alginolyticus from wild fish, identifying a low-virulence, low-resistance clade with distinct epigenetic features.

M.FcoHsdM-dependent DNA methylation coordinates secretion-associated gene expression, interbacterial competition, and virulence in Flavobacterium columnare

This study shows that M.FcoHsdM-dependent DNA methylation affects secretion systems, interbacterial competition, and virulence in Flavobacterium columnare.

Isolation, identification, and comparative genomic analysis of Vibrio harveyi as a causative agent for a skin ulcer disease of endangered fish Chinese bahaba (Bahaba taipingensis)

The paper identifies Vibrio harveyi as the causative agent of a skin ulcer disease in endangered Chinese bahaba fish and characterizes its genomic features and antimicrobial resistance.

Spatially patterned, spectral single-molecule microscopy

This paper introduces a new spectral single-molecule microscopy technique using spatially patterned detectors, achieving spectral and positional resolution without complex optical components.

A transient CD87-centred axis enhances the Th17 potential of cDC2 in neonates

The paper identifies a CD87-dependent coagulation pathway that enhances Th17 potential in neonatal cDC2, with implications for early-life immunity.

Prolonged Starvation Drives Epigenetic Remodeling: Insights from DNA Methylation Profiling in the Aquatic Pathogen Flavobacterium columnare

This study identifies epigenetic changes in Flavobacterium columnare under prolonged starvation using DNA methylation profiling, revealing motif-specific demethylation patterns linked to adaptation.