Single-molecule analysis of receptor-beta-arrestin interactions in living cells
J. Grimes, Z. Koszegi, Y. Lanoiselee, T. Miljus, S. L. O'Brien, T. M. Stepniewski, B. Medel-Lacruz, M. Baidya, M. Makarova, D. M. Owen, A. K. Shukla, J. Selent, S. J. Hill, D. Calebiro
This study uses single-molecule microscopy and simulations to show that beta-arrestin inserts into the lipid bilayer and interacts with receptors through lateral diffusion, challenging existing models of its function.
bioRxiv · Nov 15, 2022 · PreprintCell Biology