Author

T. Miljus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Le Gouill· 2 shared D. B. Veprintsev· 2 shared J. Selent· 2 shared M. Bouvier· 2 shared T. M. Stepniewski· 2 shared U. Grether· 2 shared W. Guba· 2 shared A. C. Rufer· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

C. Le Gouill

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multiple triggers converge to preferential effector coupling in the CB2R through a complex allosteric communication network

A. Morales-Pastor, T. Miljus, T. M. Stepniewski, V. Ledesma, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent

The paper investigates how multiple triggers on an allosteric communication network influence preferential coupling of the CB2R to Gi2 over β-arrestin1, revealing insights into GPCR signaling mechanisms.

bioRxiv · Feb 27, 2024 · PreprintCell Biology

Single-molecule analysis of receptor-beta-arrestin interactions in living cells

J. Grimes, Z. Koszegi, Y. Lanoiselee, T. Miljus, S. L. O'Brien, T. M. Stepniewski, B. Medel-Lacruz, M. Baidya, M. Makarova, D. M. Owen, A. K. Shukla, J. Selent, S. J. Hill, D. Calebiro

This study uses single-molecule microscopy and simulations to show that beta-arrestin inserts into the lipid bilayer and interacts with receptors through lateral diffusion, challenging existing models of its function.

bioRxiv · Nov 15, 2022 · PreprintCell Biology

Diverse chemotypes drive biased signaling by cannabinoid receptors

T. Miljus, F. M. Heydenreich, T. Gazzi, A. Kimbara, M. Rogers-Evans, M. Nettekoven, E. Zirwes, A. Osterwald, A. C. Rufer, C. Ullmer, W. Guba, C. Le Gouill, J. Fingerle, M. Nazare, U. Grether, , D. B. Veprintsev

This study identifies chemotype-specific biased signaling in cannabinoid receptors by analyzing ligand-induced signaling cascades.

bioRxiv · Nov 9, 2020 · PreprintPharmacology & Toxicology

ThermoBRET: a ligand-engagement nanoscale thermostability assay applied to GPCRs

B. L. Hoare, D. N. Tippett, A. Kaur, S. A. Cullum, T. Miljus, E. J. Koers, C. R. Harwood, N. Dijon, N. D. Holliday, D. A. Sykes, D. B. Veprintsev

ThermoBRET quantifies GPCR thermostability using BRET without labelled ligands, revealing ligand effects on protein unfolding in non-purified samples.

bioRxiv · Aug 5, 2020Biochemistry