Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
C Bravo, Alice Maria Giani, Jesús Madero‐Pérez, Zeping Zhao, Yuansong Wan, Avi J. Samelson, Man Ying Wong, Alessandro Evangelisti, Ethan Cordes, Li Fan, Pearly Ye, Daphne Zhu, Tatyana Pozner, María del Pilar Hernández Mercedes, Tark Patel, , Li Gan
The paper creates a human iPSC model of 4R tauopathy and identifies genetic modifiers of Tau propagation using CRISPRi screening.
Cell · Apr 5, 2024Peer-reviewedNeuroscience