Shengying Qin

A spectrum of altered non-rapid eye movement sleep in schizophrenia

This study replicates group-level sleep EEG differences in schizophrenia and shows increased patient-to-patient variability in NREM metrics, with medication and age-related effects contributing to this heterogeneity.

Blended Genome Exome (BGE) as a Cost Efficient Alternative to Deep Whole Genomes or Arrays

The paper introduces a cost-efficient sequencing method called Blended Genome Exome (BGE) that combines low-coverage whole genome and high-coverage exome data, achieving >99% concordance with 30x WGS for variant imputation and rare coding variant calling.

Improving Polygenic Prediction in Ancestrally Diverse Populations

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

This study identifies NREM sleep and wake EEG biomarkers associated with schizophrenia symptom severity and disease status.

Comparative genetic architectures of schizophrenia in East Asian and European populations

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.