Yue Yin

Pan-cancer nucleosome landscapes reveal tumor heterogeneity and inform cell-free DNA-based detection

The paper characterizes nucleosome organization across 23 cancer types using ATAC-seq and shows its utility for cancer classification and detection using cell-free DNA.

TRiC-assisted folding of class I HDAC family proteins regulated by distinct co-chaperone and cofactor networks

This study elucidates the TRiC-assisted folding of class I HDACs, revealing distinct co-chaperone and cofactor networks for HDAC1 and HDAC3, while HDAC8 folds independently.

Mechanisms of Ub-independent ODC recognition and translocation by the 26S proteasome revealing proteasome's functional adaptability

This study reveals the mechanism by which the 26S proteasome recognizes and degrades ODC without ubiquitin, through cryo-EM structures showing dynamic interactions and translocation processes.

Asymmetric binding of coactivator SRC1 to FXR-RXR and allosteric communication within the complex

This study reveals the asymmetric binding of SRC1 to FXR-RXR and the allosteric communication within the complex, providing a structural model for understanding FXR function and its disease implications.