Tomoko Nishiyama

Region-specific generation and retention of acetylated cohesin shape the genome-wide pattern of sister chromatid cohesion

The paper investigates how ESCO2-mediated acetylation of cohesin is distributed and retained across the genome, revealing region-specific patterns and post-replicative retention mechanisms.

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

This study shows cohesin maintains condensed euchromatic domains in human cells by preventing local mixing, which is crucial for transcriptional insulation.

AT-hook-dependent DNA loop extrusion by STAG1 drives 3D genome folding

This study shows that STAG1's AT-hook motif enhances DNA loop extrusion by cohesin, driving 3D genome folding, while STAG2 lacks this feature.

Functional interplay between condensin I and topoisomerase IIα in single-molecule DNA compaction

This study shows how condensin I and topoisomerase IIα work together to compact DNA into stable structures at the single-molecule level.