Author

Jouni Härkönen

Åbo Akademi UniversityORCID 0000-0002-1201-4288Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Johanna IvaskaiD· 4 shared Gautier FollainiD· 3 shared Monika VaitkevičiūtėiD· 3 shared Guillaume JacquemetiD· 2 shared Hellyeh HamidiiD· 2 shared Joanna W. PylvänäineniD· 2 shared Aleksi IsomursuiD· 1 shared Anna-Mari Haapanen-SaaristoiD· 1 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCell Biology

Johanna IvaskaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity

Nicolas Pasquier, Meri Pelkonen, Elise Carraz-Billat, Aleksi Isomursu, Raphaël Merand, Hellyeh Hamidi, Jacques R.R. Mathieu, Jouni Härkönen, Gautier Follain, Christophe Desterke, Zoé Fusilier, Junel Solis, Irina Belaya, Pasi Kankaanpää, Valeria Barresi, , Johanna Ivaska

The paper identifies a signaling axis involving SorLA, integrin, and HER2/HER3 that regulates apicobasal polarity in mucinous colorectal adenocarcinoma and shows its therapeutic relevance.

Nature Communications · Jul 4, 2026Peer-reviewedCancer Biology

Scaffold protein SHANK3 regulates endothelial cell motility and tissue mechanics

Megan R. Chastney, Anne Pink, Jouni Härkönen, Gautier Follain, Vanessa Stuve, Joanna W. Pylvänäinen, Anna-Mari Haapanen-Saaristo, Jenna Villman, Monika Vaitkevičiūtė, Giorgio Scita, Ilkka Paatero, Guillaume Jacquemet, Fabio Giavazzi, Pipsa Saharinen, Johanna Ivaska

This study shows SHANK3 regulates endothelial cell motility and tissue mechanics, affecting vascular development in zebrafish and mice.

bioRxiv · Apr 13, 2026 · PreprintCell Biology

Leupaxin inhibits the durotaxis and mechanosensitivity of metastatic breast cancer cells

Mathilde Mathieu, Jouni Härkönen, Monika Vaitkevičiūtė, Hellyeh Hamidi, Johanna Ivaska

This study shows that leupaxin inhibits durotaxis and mechanosensitivity in metastatic breast cancer cells by disrupting paxillin-FAK signaling.

bioRxiv · Feb 3, 2026 · PreprintCell Biology

Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers

Gautier Follain, Sujan Ghimire, Joanna W. Pylvänäinen, Monika Vaitkevičiūtė, Iván Hidalgo-Cenalmor, Diana H Wurzinger, Camilo Guzmán, James R. W. Conway, Michal Dibus, Jouni Härkönen, Sanna Oikari, Kirsi J. Rilla, Marko Salmi, Johanna Ivaska, Guillaume Jacquemet

This study uses fast label-free live imaging and deep learning to analyze cancer cell arrest on endothelial monolayers, finding CD44-HA interactions and flow dynamics are key factors.

The EMBO Journal · Jan 6, 2026Peer-reviewedCell Biology