Author

Thomas J. C. Collins

Baker Heart and Diabetes InstituteORCID 0000-0002-8044-2815Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Andrew James MurphyiD· 2 shared Peter J. MeikleiD· 2 shared Pooranee K. MorganiD· 2 shared Andrew Donald CloustoniD· 1 shared Camilla Bertuzzo VeigaiD· 1 shared Daniel G. BlackmoreiD· 1 shared Dave BoucheriD· 1 shared Emmanuelle Frampton· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Andrew James MurphyORCID

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2 papers

Recent·Most cited

A diet enriched in highly poly-unsaturated fatty acids alters immune cell lipid composition and ferroptosis susceptibility

Pooranee K. Morgan, Yangsong Xu, Thomas J. C. Collins, Camilla Bertuzzo Veiga, Natalie A. Mellet, Kevin Huynh, Peter J. Meikle, Andrew James Murphy, Graeme Iain Lancaster

This study shows that a high PUFA diet increases PL-PUFA content in immune cells and enhances their susceptibility to ferroptosis.

bioRxiv · Oct 21, 2026 · PreprintCell Biology

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

Sabrina Sofia Burgener, Mark Thomas Milner, Shoumit Dey, Pooranee K. Morgan, Daniel G. Blackmore, Emmanuelle Frampton, Gregory C. Miller, Monalisa Duarte de Oliveira, Kirsten Myra Kenney, Rinie Bajracharya, Ulrich Baumgartner, Thomas J. C. Collins, Zherui Xiong, Quan Hoang Nguyen, Peter J. Meikle, , Kate Schroder

This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.

bioRxiv · Apr 28, 2025 · PreprintImmunology