Edward Perez‐Reyes

Gene therapy with doxycycline-controlled expression of human Kv1.1 reduces neuronal excitability and increases sociability of Scn2a-deficient mice

This study shows that inducing Kv1.1 expression in Scn2a-deficient mice reduces neuronal hyperexcitability and improves sociability without affecting wild-type mice.

Seizures induce c-fos expression in a subset of astrocytes, termed fostrocytes, that dampen subsequent seizures

The paper identifies a subset of astrocytes, called fostrocytes, that express c-fos after seizures and show anti-seizure effects when their activity is increased.

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

Microglia play beneficial roles in multiple experimental seizure models.

This study demonstrates that microglia have a beneficial role in reducing various types of seizures using a targeted approach.

LMO7 deficiency reveals the significance of the cuticular plate for hearing function

This study identifies LMO7 as a hair cell protein localized to the cuticular plate, showing that its deficiency leads to structural defects and progressive hearing loss.