rRNA transcription is integral to liquid-liquid phase separation and maintenance of nucleolar structure
Soma Dash, Maureen C. Lamb, Jeffrey J. Lange, Mary Cathleen McKinney, Dai Tsuchiya, Fengli Guo, Xia Zhao, Timothy J. Corbin, MaryEllen Kirkman, Kym M. Delventhal, Emma L. Moore, Sean McKinney, Rita Shiang, Paul A. Trainor
The paper shows that rRNA transcription by Pol I is essential for nucleolar structure and liquid-liquid phase separation in mouse embryos.
bioRxiv · Nov 14, 2022 · PreprintDevelopmental Biology