The paper identifies SMARCA1 as a key regulator in colorectal cancer metastasis through analysis of histone modification recognition proteins in cancer cell lines.

Genes & Diseases · Dec 24, 2025Peer-reviewedCancer Biology

In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery

Saijuan Xu, Dan Liang, Qiudao Wang, Yan Cheng, Da Xie, Gui Yang, Haokun Zhang, Changrui Feng, Feiyan Zhao, Wendan Ren, Gongrui Sun, Yang Yang, Lin Li, Yongrong Lai, Bin Fu, , Yuxuan Wu

This paper develops an antibody-free lipid nanoparticle system for in vivo mRNA delivery to human HSCs, enabling efficient base editing of HBG to treat blood disorders like beta-thalassemia and sickle cell disease.

Nature Biomedical Engineering · Aug 12, 2025Peer-reviewedBioengineering

Dynamic regulation and requirement for ribosomal RNA transcription duringmammalian development

Karla T. Falcon, Kristin E. Noack Watt, Soma Dash, Ruonan Zhao, Daisuke Sakai, Emma L. Moore, Sharien Fitriasari, Melissa Childers, Mihaela E. Sardiu, Selene K. Swanson, Dai Tsuchiya, Jay R. Unruh, George Bugarinovic, Lin Li, Rita Shiang, , Paul A. Trainor

The paper shows that disruptions in Pol I rRNA transcription specifically affect craniofacial development by causing NCC apoptosis and craniofacial anomalies in mice.

Proceedings of the National Academy of Sciences · Jul 26, 2022Peer-reviewedDevelopmental Biology