Wei Yang

Diffusing protein binders to intrinsically disordered proteins

The paper develops RFdiffusion to generate protein binders for IDPs/IDRs, achieving nanomolar affinity and functional applications in amylin and IL2RG.

Design of intrinsically disordered region binding proteins

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy

This paper introduces PSEs, bifunctional molecules that enhance phagocytosis and block PD-L1, showing improved antitumor responses in animal models.

Accurate Computational Design of 3D Protein Crystals

This paper designs 3D protein crystals with specified lattice architectures using computational methods, achieving atomic accuracy and demonstrating successful experimental validation.

Robust de novo design of protein binding proteins from target structural information alone

This paper designs small, stable proteins that bind to diverse target proteins using only structural information, achieving nanomolar to picomolar affinities.