Selcan C. Aydin

The Flame Retardant Triphenyl Phosphate Induces Varying Responses in Genetically Diverse Mouse Induced Pluripotent Stem Cells

The study examines how genetic variation in mouse induced pluripotent stem cells affects gene expression and cell cycle responses to triphenyl phosphate exposure.

A panel of Diversity Outbred mouse embryonic stem cells: enabling the functional characterization of natural genetic variation in vitro

The paper describes a panel of genetically diverse embryonic stem cells from Diversity Outbred mice to study natural genetic variation's impact on pluripotency and differentiation.

Chromosome X Dosage Modulates Development of Aneuploidy in Genetically Diverse Mouse Embryonic Stem Cells

The paper identifies that X chromosome dosage influences aneuploidy development in mouse embryonic stem cells, with XO and XY lines showing higher aneuploidy rates than XX lines.

Molecular and genetic heterogeneity in iPSCs derived from an outbred laboratory mouse population

The paper generates a genetically diverse panel of iPSCs from a mouse population and identifies regulatory loci influencing gene expression variation.

Simplifying Systems Genetics with QTLretrievR: An R Package for Molecular QTL Identification

QTLretrievR simplifies molecular QTL identification in genetically diverse populations by integrating existing tools with parallelization, reducing computational time and improving accessibility.

Cross cell-type systems genetics reveals the influence of eQTL at multiple points in the developmental trajectory of mouse neural progenitor cells

The paper identifies eQTL in mouse neural progenitor cells and shows their effects on gene regulation across developmental stages.

Genetic dissection of the pluripotent proteome through multi-omics data integration

This study integrates multi-omics data from mouse embryonic stem cells to identify genetic drivers of proteome variability and uncover regulatory mechanisms in pluripotency.

An in vitro neurogenetics platform for precision disease modeling in the mouse

This paper develops a cross-species platform to model human disease using genetically diverse mouse and human stem cells, showing that DYRK1A loss of function effects vary with genetic background.

Genetic variation influences pluripotent ground state stability in mouse embryonic stem cells through a hierarchy of molecular phenotypes

The paper identifies genetic variants influencing metastability in mouse embryonic stem cells by analyzing gene expression and chromatin accessibility in 185 genetically diverse cells.