Ralph Steven Baric

The paper identifies a genetic locus associated with coronavirus disease susceptibility in mice and shows its relevance to human severe COVID-19 outcomes.

This study evaluates the antiviral efficacy of GS-5245 against multiple SARS-CoV-2 variants and other coronaviruses, showing broad in vitro activity and protective effects in animal models.

This paper demonstrates that MM3122, a host cell serine protease inhibitor, effectively inhibits SARS-CoV-2 replication and reduces disease severity in mice, both prophylactically and therapeutically.

This study develops a trivalent RBD nanoparticle vaccine that protects mice against both merbecovirus and sarbecovirus challenges, including SARS-CoV, MERS-CoV, and SARS-CoV-2.

This paper introduces a semi-quantitative lateral flow assay that correlates with neutralizing antibody levels in SARS-CoV-2 recovered individuals.

This study shows that MA10 SARS-CoV-2 infection in mice leads to neuropathological changes in the hippocampus, mirroring the prevalence of Long COVID in humans.

The paper uses CRISPR screens to identify mucins as key host factors that restrict SARS-CoV-2 infection in human lung cells.

The paper identifies genetic factors influencing immune cell populations in lung tissue and their predictive value for influenza outcomes in Collaborative Cross mice.

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

The paper tests Collaborative Cross mice as an immune-competent model for ZIKV infection, finding poor infection and low antibody response.

The paper uses a diallel analysis in mice to study how host genetics affect response to influenza A virus, identifying Mx1-dependent and independent heritable effects on weight loss.