Yvan Arsenijévic

The paper develops an in vitro method to study how guide RNAs affect RNA editing and splicing, finding that editing can both disrupt and improve splicing outcomes depending on the target site.

This study shows that glutamylation imbalance in photoreceptor cells leads to structural defects and degeneration, highlighting its role in maintaining outer segment architecture.

The paper models RLBP1-related retinal diseases using iPSC-derived RPE and validates a gene replacement strategy, identifying a novel CRALBP isoform with functional significance.

This study fine-tunes FAM161A gene therapy in mice to restore retinal function by optimizing promoter activity, dosage, and isoform delivery.