Lei Sun

Agentic transcranial functional ultrasound imaging: @fUS

The paper introduces @fUS, an agentic transcranial fUS imaging platform that enables functional brain imaging in mice with high spatial and temporal resolution, supporting longitudinal studies without surgery.

β-cell-specific Non-invasive Ultrasound Stimulation to Enhance Insulin Release and Glucose Control in Mice

This study uses ultrasound with microbubbles to stimulate beta-cells in mice, enhancing insulin release and reducing blood glucose levels without tissue damage.

Miniaturized and accessible functional ultrasound imaging system for freely moving mice

This paper introduces a miniaturized functional ultrasound imaging system for freely moving mice, achieving high-resolution brain activity mapping with improved accessibility and performance.

Ultrasound Directly Activates Sparse Neurons and Modulates Visual Circuits in Deafened Mice

This study shows ultrasound directly activates sparse neurons in deafened mice, modulates visual circuits, and confirms direct mechanical effects independent of auditory input.

Functional Imaging of Developing Brain in Mice and Non-Human Primates

This study uses functional ultrasound to monitor brain activity in developing mice and non-human primates, revealing neural activity patterns and responses to external stimuli.

The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation

This study shows that Piezo1 mediates ultrasound neuromodulation in the brain by demonstrating reduced neuronal responses in Piezo1 knockout mice.

The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia

This study shows that Piezo1 modulates microglia migration and immune responses by affecting cytokine production and stiffness sensing.

Circuit-specific sonogenetic stimulation of the deep brain elicits distinct signaling and behaviors in freely moving mice

This study demonstrates that sonogenetics can selectively activate defined neural circuits and induce specific behaviors in freely moving mice through ultrasound stimulation.

Candidate Explorer: a tool for discovery, evaluation, and display of mutations causing significant immune phenotypes

Candidate Explorer identifies causative mutations for immune phenotypes by integrating multiple data features into a score, improving mutation-phenotype association verification in mice.

Ultrasound neuromodulation through nanobubble-actuated sonogenetics

This paper demonstrates a method using gas-filled nanostructures to enhance and selectively control ultrasound neuromodulation of neurons.

Estrogen accelerates heart regeneration by promoting inflammatory responses in zebrafish

This study shows estrogen accelerates heart regeneration in zebrafish by enhancing inflammatory responses, which can be modulated by estrogen antagonists.