Dagmar Wilhelm

Ovarian development is driven by early spatiotemporal priming of the coelomic epithelium

This study shows that ovarian cellular diversity arises from spatially organized, transcriptionally heterogeneous coelomic epithelium progenitors in fetal mouse and human ovaries, which are primed toward supporting or steroidogenic identities.

NEDD4 promotes Sertoli cell proliferation and adult Leydig cell differentiation in the murine testis

This study identifies NEDD4's role in promoting Sertoli cell proliferation and adult Leydig cell differentiation in murine testis development through PI3K-AKT signaling and steroidogenesis.

Testicular sex cord stromal tumors in mice with constitutive activation of PI3K and loss of Pten

This study investigates the role of PI3K pathway activation and Pten loss in testicular tumors in mice, finding aggressive tumors with immune cell infiltration patterns.

TRIM28-dependent SUMOylation protects the adult ovary from the testicular pathway

This study identifies TRIM28's role in preventing female-to-male sex reversal in the adult mouse ovary by maintaining the ovarian pathway through SUMOylation.

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad

The paper identifies and characterizes a previously uncharacterized supporting-like cell lineage in developing mouse gonads, showing its origin, specification, and sex-specific differentiation.