Elaine Y. Hsiao

Consumption of processed foods impairs memory function through dietary advanced glycation end-products

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.

Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice

This study shows that dietary fiber in ketogenic diets affects the gut microbiome and seizure resistance in mice, with fiber content being more influential than fat type or ratio.

Vagal interoception of microbial metabolites from the small intestinal lumen

This study shows that gut microbiota influences vagal nerve activity through metabolites, which activate specific receptors and neurons involved in gut-brain communication.

Cross-tissue multiomics reveals that Akkermansia muciniphila counteracts metabolic syndrome by reprograming gut microbiota, oleoylethanolamide and the gut-hypothalamus axis

This study identifies oleoylethanolamide (OEA) as a key mediator by which Akkermansia muciniphila alleviates fructose-induced metabolic syndrome through gut microbiota and gut-hypothalamus axis modulation.

Gut microbial taxa elevated by dietary sugar disrupt memory function

This study shows that early life sugar consumption alters gut microbiota and impairs hippocampal-dependent memory in rats, with specific bacterial taxa linked to these effects.

Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to High Fructose Consumption in Mice

This study shows that gut microbiota differences between mouse strains contribute to varied metabolic responses to high fructose consumption, with Akkermansia playing a key protective role.