Paulino Barragán‐Iglesias

This study investigates the mechanism of BoNT/A1 in human sensory neurons, showing it disrupts SNARE complexes and reduces neurotransmitter release through transcriptomic analysis.

The paper identifies sex differences in nociceptor translatomes, revealing sex-specific prostaglandin signaling differences in male and female mice.

The paper identifies Arc as an activity-dependent gene involved in neurogenic inflammation through intercellular signaling via extracellular vesicles.

This study shows type I interferons act directly on nociceptors via MNK-eIF4E signaling to cause pain hypersensitivity in mice, linking viral infections to pain and neuropathies.

The paper compares transcriptomes of native and cultured human and mouse dorsal root ganglia, finding reduced neuronal gene expression in culture but presence of key pharmacological targets.

The paper identifies the RagA-mTORC1 network as a key driver of neuropathic pain through cell-specific translational profiling in nociceptors.