Author

Yan Wu

Chinese Academy of SciencesORCID 0000-0003-2734-0673Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yan Wu7 papers · Syracuse University

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alex InagueiD· 1 shared Alexis ScherliD· 1 shared Amy Shelton· 1 shared Cecile C. de la Cruz· 1 shared Chang‐Qiang Ke· 1 shared Charisa CottonhamiD· 1 shared Chris Siebel· 1 shared Ciara MetcalfeiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperBioengineering

Alex InagueORCID

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintJun 6, 2025

Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery

Fangzhu Zhao, Yan Wu, Kaitlin Schaefer…·James A. Wells

This paper develops LIPTACs, LDLR-targeting chimeras that enhance lysosomal delivery and cytotoxicity for cancer treatment by combining eTPD and ADC strategies.

4 citations

proteomicsexperimental assay

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Cancer BiologybioRxivPreprintDec 13, 2024

Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma

Kerstin Seidel, Robert Piskol, Thi Thu Thao Nguyen…·Chris Siebel

This study identifies Notch-dependent progenitor-like HCCs that regress upon Notch inhibition, revealing a therapeutic target in a poor-prognosis subgroup.

1 citation

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintApr 13, 2020

✦ In-depth digest

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro

Haixia Su, Sheng Yao, Wenfeng Zhao…·Yechun Xu

Baicalin and baicalein from Scutellaria baicalensis inhibit SARS-CoV-2 3CL protease non-covalently; a 2.2 Å baicalein complex structure shows an unusual shield-like binding mode.

143 citations

virusprotein structure

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