Maria João Amorim

This study shows that age-related decline in adipose tissue lipolysis reduces disease tolerance to SARS-CoV-2, increasing mortality in older mice and correlating with human COVID-19 severity.

The paper identifies unconjugated bilirubin as a protective metabolite against malaria by inhibiting parasite proliferation and hemozoin formation.

This paper shows that a commensal Streptococcus mitis strain prevents secondary pneumococcal pneumonia by inhibiting pneumococcal colonization and dissemination through bacteriocins.

This study shows that membrane association stabilizes suboptimal membrane proteins like IAV M2, preventing premature degradation and enhancing biogenesis efficiency.

This study shows that the influenza A virus M2 viroporin can use multiple membrane insertion pathways, including EMC and Oxa1-family translocons, ensuring robust viral infection.

The paper uses AlphaFold to predict structures of host-pathogen PPIs, revealing molecular mimicry modes and convergent evolution of interaction interfaces.

This study shows that the EMC3 subunit is critical for lipid droplet homeostasis in mice and Drosophila, with loss of EMC3 causing triglyceride storage defects and reduced FITM2 levels.

This study shows segmented negative-strand RNA viruses use upstream translation initiation to expand their coding capacity through non-AUG initiation and host mRNA leader sequence appropriation.