The paper examines complement activation dynamics in acute ischemic stroke patients and controls, finding pathway-specific markers associated with outcomes.

Journal of the American Heart Association · Oct 16, 2026Peer-reviewedNeuroscience

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

Emma CB Wall, José Afonso Guerra‐Assunção, Marie Yang, Rutger Konig, Teerawit Audshasai, Alize M Proust, Rieza Aprianto, Elisa Ramos‐Sevillano, Giuseppe Ercoli, Nicola Bordin, V. S. Agostinho-Terra, Jan‐Willem Veening, David Griffith Lalloo, Brendan William Wren, Robert John Wilkinson, , Jeremy Brown

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

bioRxiv · Apr 30, 2024 · PreprintMicrobiology

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

John A. Lees, Bart Ferwerda, Philip H. C. Kremer, Nicole E. Wheeler, Mercedes Valls Serón, Nicholas J. Croucher, Rebecca A. Gladstone, Hester J. Bootsma, Nynke Y. Rots, Alienke J. Wijmenga‐Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzciński, Anne L. Wyllie, Aeilko Having Zwinderman, Leonard H. van den Berg, , Diederik van de Beek

The paper uses genome-wide association studies to show human and pneumococcal genetic variation influences susceptibility and severity of pneumococcal meningitis.

Nature Communications · May 15, 2019Peer-reviewedGenomics