Shari Pilon‐Thomas

This paper shows that reducing BCL11B in CD8+ T cells enhances anti-tumor response by preventing exhaustion and boosting stemness and cytotoxicity.

This study shows that dual stimulation of CD40 and 41BB pathways using a bi-specific molecule enhances CD8+ T cell expansion in TIL cultures.

This paper develops a virtual cohort framework to stratify individuals into treatment subgroups and applies it to a murine bladder cancer dataset to generate synthetic mice replicating tumor dynamics and experimental outcomes.

This paper uses an agent-based model to simulate how different treatment-free intervals during T-cell engager exposure affect T cell exhaustion and tumor control in B-ALL.

This paper demonstrates that magnetoelectric nanoparticles (MENPs) can target and kill cancer cells via irreversible electroporation when activated by MRI, showing significant tumor volume reduction with no toxicities.

PETIL predicts TIL expansion in bladder cancer using demographic, clinical, and biological features, achieving AUC values of 0.740 and 0.857 in testing and validation cohorts.

This study develops a PROTAC that degrades HPV E6 protein, reducing tumor burden in a mouse model and showing immune dependence.

The paper optimizes vaccine and anti-PD1 combination therapy for melanoma by using a mathematical model and optimization algorithm to determine the best treatment protocol.