Author

Patrick Hwu

Moffitt Cancer CenterORCID 0000-0002-8293-1313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Joseph JohnsoniD· 2 shared Shari Pilon‐ThomasiD· 2 shared Ahmad A. TarhiniiD· 1 shared Ahmed RamadaniD· 1 shared Alex Alfaro· 1 shared Alyssa ObermayeriD· 1 shared Amod SarnaikiD· 1 shared Anthony E. Alleyne· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Joseph JohnsonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Spatially resolved multimodal hallmarks of response to neoadjuvant immunotherapies in the melanoma ecosystem in 2D and 3D

Zichao Liu, Xiaofei Song, Wei-Shen Chen, Shikhar Dhingra, Jiang He, Lizhi He, Chengyi Chen, Jodi A. Balasi, Zena Sayegh, Carlos M. Moran Segura, Neale Lopez-Blanco, Anthony E. Alleyne, Jonathan V. Nguyen, Joseph Johnson, Douglas C. Marchion, , Pei-Ling Chen

The paper analyzes the spatial molecular architecture of melanoma tumors under different immunotherapy regimens and identifies biomarkers predicting response to treatment.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology

BCL11B targeting in tumor CD8+ T cells amplifies anti-tumor response by blocking exhaustion while promoting stemness and cytotoxicity

Leonardo Silvane, Τόμας Ζελένκα, Divya Priyanka Talada, Valeriu Bogdan Cismasiu, Shamima Islam, Raghwendra P. Singh, Zefanias Ngove, Sayan Chakraborty, MacLean S. Hall, Jamie L. Blauvelt, Erika Adriana Eksioglu, Soraya Zorro Manrique, Joseph Johnson, Alyssa Obermayer, Alex Alfaro, , Dorina Avram

This paper shows that reducing BCL11B in CD8+ T cells enhances anti-tumor response by preventing exhaustion and boosting stemness and cytotoxicity.

bioRxiv · Aug 7, 2026 · PreprintImmunology

Dual stimulation of CD40 and 41BB pathways during ex-vivo TIL expansion enhances CD8+ T cell expansion

R. A. M. Rossetti, Matthew S. Beatty, Junior Cianne, Johannes R. Ali, Kylie Harris, Ahmed Ramadan, Michael Grant, Elena Martinez Planes, Jyllica Aurelio, Lilit Karapetyan, Ben Creelan, Shari Pilon‐Thomas, Patrick Hwu, Vincent C. Luca, Daniel Abate‐Daga

This study shows that dual stimulation of CD40 and 41BB pathways using a bi-specific molecule enhances CD8+ T cell expansion in TIL cultures.

bioRxiv · Jul 26, 2026 · PreprintImmunology