Kerstin Voelkl

snRNA-seq of Huntington's disease mice reveals vulnerability profiles of cortical cell types

This study uses snRNA-seq to analyze cortical cell types in HD mice, revealing differential vulnerability and identifying ER-phagy as a protective pathway in HD.

Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease

This study shows that hepatoma-derived growth factor (HDGF) has neuroprotective effects in Huntington's disease models by reducing mutant Huntingtin toxicity and aggregation.

Novel proteostasis reporter mouse reveals different effects of cytoplasmic and nuclear aggregates on protein quality control in neurons

The paper develops a mouse model with a proteostasis reporter to study how cytoplasmic and nuclear protein aggregates affect neuronal protein quality control in aging and disease.

Cortical circuit alterations precede disease onset in Huntington’s disease mice

This study shows that cortical circuit alterations, including increased neuronal activity and reduced inhibitory synapses, occur before disease onset in Huntington’s disease mice.