Pål Sætrom

Pyranges v1: a Python framework for ultrafast sequence interval operations

Pyranges v1 provides a Python framework for efficient sequence interval operations, offering speed and functionality improvements over existing tools like BEDTools.

Whole genome CRISPR knockout screen reveals ID3 as a key regulator of myeloma cell survival via TCF3 and c-MYC

Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory

This study shows that loss of Aag in mice reduces DNA damage and alters gene expression in the brain, leading to reduced anxiety and improved memory.

Persistence of Cajal-Retzius cells in the postnatal hippocampus is required for development of dendritic spines of CA1 pyramidal cells

This study shows that persistent Cajal-Retzius cells in the postnatal hippocampus are essential for the development of dendritic spines in CA1 pyramidal cells.

Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation

The paper identifies non-coding RNAs involved in cell cycle regulation by analyzing RNA, RNA polymerase II, and promoter activity changes across the cell cycle in human keratinocytes.

The G2-phase enriched lncRNA SNHG26 is necessary for proper cell cycle progression and proliferation

This study shows that SNHG26, a G2-phase enriched lncRNA, is necessary for cell cycle progression and proliferation, with effects on mitochondrial stress and gene expression.

The lncRNA EPB41L4A-AS1 regulates gene expression in the nucleus and exerts cell type-dependent effects on cell cycle progression

NEIL1 and NEIL2 DNA glycosylases regulate anxiety and learning in a cooperative manner

This study shows that NEIL1 and NEIL2 DNA glycosylases work together to regulate anxiety and learning in mice, despite not affecting oxidative DNA damage levels.

Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression

The paper shows AAG associates with transcription elongation to coordinate DNA repair with gene expression, revealing roles of aberrantly methylated bases in gene regulation.

PyRanges: efficient comparison of genomic intervals in Python

PyRanges provides a fast and memory-efficient data structure for genomic interval operations in Python, outperforming R's GenomicRanges library.