Seth G. N. Grant

The paper estimates synapse numbers in the hippocampus and brain-wide using electron microscopy and genetic labeling, finding high densities in isocortex and olfactory areas, and low densities in pallidum and cerebellum.

The paper maps the human synaptome, finding conserved synaptic features between humans and mice despite evolutionary divergence.

The paper reveals a lifespan program of synaptome architecture changes in the mouse brain, showing differentiation and dedifferentiation phases across brain circuits.

The paper develops methods to specifically visualize and isolate endogenous synaptic proteins in mice, revealing differences in PSD95 complex composition across cell types.

The paper identifies synaptic protein combinations that underlie diverse innate and learned behaviors in mice, showing their role in behavioral repertoire expansion and disease susceptibility.

The paper identifies a combinatorial molecular mechanism in synapses that converts nerve impulse patterns into diverse behavioral responses across species and timescales.

The paper identifies regional differences in the postsynaptic proteome across mouse brain regions using proteomic mass spectrometry, revealing unique compositional signatures correlated with anatomy and embryology.