Marisa M. Brockmann

Ire1α-Regulated mRNA Translation Rate Controls the Identity and Polarity of Upper Layer Cortical Neurons

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

Reexamination of N-terminal domains of Syntaxin-1 in vesicle fusion from central murine synapses

This study reexamines the roles of Syntaxin-1's N-peptide and Habc-domain in synaptic vesicle fusion using a mouse model, showing the Habc-domain is essential while the N-peptide has regulatory functions.

Bi-allelic variants in TSPOAP1, encoding the active zone protein RIMBP1, cause autosomal recessive dystonia

The paper identifies bi-allelic variants in TSPOAP1 as a cause of autosomal recessive dystonia, showing different clinical presentations based on variant type.

Functional architecture of the synaptic transducers at a central glutamatergic synapse

The paper reveals a nanoscale tripartite complex at glutamatergic synapses formed by Ca2+-channels, vesicles, and AMPA receptors, showing their functional coordination in neurotransmission.

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

This study shows RIM-BP2 has different roles in neurotransmitter release at hippocampal mossy fiber and pyramidal CA3-CA1 synapses, with RIM-BP2 promoting vesicle docking/priming at mossy fibers by recruiting Munc13-1.