Author

Thomas A. Johnson

National Institutes of HealthORCID 0000-0002-9135-3252Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gordon L. HageriD· 4 shared Alba Jiménez‐PanizoiD· 3 shared Andrea Alegre‐MartíiD· 3 shared Eva Estébanez‐PerpiñáiD· 3 shared Juan Fernández‐RecioiD· 3 shared Kaustubh WaghiD· 3 shared Agustina L. LafuenteiD· 2 shared Arpita UpadhyayaiD· 2 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersMolecular Biology

Gordon L. HagerORCID

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4 papers

Recent·Most cited

The multimerization pathway of the glucocorticoid receptor

Andrea Alegre‐Martí, Alba Jiménez‐Panizo, Agustina L. Lafuente, Thomas A. Johnson, Inés Montoya-Novoa, Maria Nuria Peralta-Moreno, Pilar Montanyà-Valluguera, Josep Ponsetí-Pons, Montserrat Abella, Sohyoung Kim, Mireia Díaz, Marta Vilaseca, Paloma Pérez, Juan Fernández‐Recio, J. Rubio, , Eva Estébanez‐Perpiñá

The paper presents a new crystal structure of agonist-bound GR-LBD and proposes a model for GR multimerization, reconciling structural and functional data on glucocorticoid resistance.

Nucleic Acids Research · Sep 18, 2025Peer-reviewedBiochemistry

Bile acids target an exposed cavity in the glucocorticoid receptor modulating receptor self-assembly, chromatin binding and transcriptional activity

Alba Jiménez‐Panizo, Thomas A. Johnson, Kaustubh Wagh, Andrea Alegre‐Martí, Inés Montoya-Novoa, Agustina L. Lafuente, Ulrich Eckhard, Luis Angel Rodríguez‐Lumbreras, Le Hoang, Martín Stortz, Montserrat Abella, Ido Goldstein, Annabel F. Valledor, Lyuba Varticovski, Irwin M. Arias, , Eva Estébanez‐Perpiñá

This study shows bile acids bind to an exposed cavity on the glucocorticoid receptor, affecting its self-assembly and transcriptional activity.

bioRxiv · May 13, 2025 · PreprintMolecular Biology

Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers

Grégory Fettweis, Kaustubh Wagh, Diana A. Stavreva, Alba Jiménez‐Panizo, Sohyoung Kim, Michelle Lion, Andrea Alegre‐Martí, Lorenzo Rinaldi, Thomas A. Johnson, Elise Gilson, Manan Krishnamurthy, Li Wang, David A. Ball, Tatiana Karpova, Arpita Upadhyaya, , Gordon L. Hager

The paper identifies LxxLL motifs in NIPBL that regulate its interaction with MAU2 and steroid receptors, forming a ternary complex with GR to facilitate enhancer localization of cohesin.

Nucleic Acids Research · May 10, 2025Peer-reviewedMolecular Biology

The Glucocorticoid Receptor is Required for Efficient Aldosterone-Induced Transcription by the Mineralocorticoid Receptor

Thomas A. Johnson, Grégory Fettweis, Kaustubh Wagh, Brian Almeida‐Prieto, Manan Krishnamurthy, Arpita Upadhyaya, Gordon L. Hager, Diego Álvarez de la Rosa

This study shows that GR co-expression enhances MR transcriptional activity in response to aldosterone, even without glucocorticoids.

bioRxiv · Jan 26, 2023 · PreprintMolecular Biology