Jurjen Justin Luykx

The paper examines the associations of APOE ε2/ε4 dosage and lifestyle on neuroimaging markers in the UK Biobank, finding no significant interaction between lifestyle and APOE dosage.

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

The paper replicates an antidepressant response polygenic risk score (PRS-AR) in an independent trial and shows drug-specific effects and improved remission rates with stratification.

The paper integrates single-cell transcriptomic data with genome-wide association studies to identify neuronal cell types consistently implicated in neuropsychiatric disorders.

This study investigates the genetic and environmental overlap and bidirectional causality between resilience and well-being using twin-sibling data and polygenic scores.

This study identifies strong genetic correlations between genetic generalized epilepsy and background EEG oscillations, particularly in the beta frequency band, suggesting shared biological mechanisms.

The paper identifies nine clinical phenotypes and polygenic risk scores associated with quality of life in schizophrenia patients and their relatives.

The paper identifies genetic differences in BMI between tall and short individuals using UK Biobank data, finding height-specific loci and differential effects on BMI and related traits.

The paper investigates how polygenic risk for schizophrenia interacts with childhood adversity to influence emotional dysregulation and psychosis proneness in adolescents and young adults.

This study identifies dysregulation of coding, long non-coding, circular RNA, and alternative splicing in bipolar disorder using postmortem brain tissue.

Cross-disorder meta-analysis of eight psychiatric GWAS (232,964 cases, 494,162 controls) reports 109 loci shared by two or more disorders and three groups of correlated disorders.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

This study uses pathway analysis on schizophrenia GWAS data to identify enrichment in synaptic plasticity and neurotransmitter synapse gene sets, supporting a role for postsynaptic signaling in schizophrenia.

This study uses Mendelian randomization to examine if genetic variants influencing C-reactive protein levels are associated with post-ICU PTSD and depression, finding no significant associations.