Marie Vestergaard Lukassen

Generalizable direct protein sequencing with InstaNexus

This paper introduces a workflow for direct protein sequencing using AI-driven methods, validated across diverse proteins to improve accuracy and reduce ambiguity in therapeutic and scientific applications.

Alligamycin A, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

This paper identifies alligamycin A, a novel antifungal compound from Streptomyces iranensis, and demonstrates its potent antifungal activity against clinically relevant fungi.

Longitudinal fluctuations in protein concentrations and higher-order structures in the plasma proteome of kidney failure patients subjected to a kidney transplant

This study tracks longitudinal changes in the plasma proteome and complexome of kidney failure patients before and after transplantation, revealing acute phase protein dynamics and macromolecular complex formation during inflammation.

A germline PAF1 paralog complex ensures cell type-specific gene expression

The paper shows that testis-specific PAF1C paralogs (tPAF) are essential for transcription termination and cell type-specific gene expression in Drosophila spermatocytes.

CD5L is a canonical component of circulatory IgM

The paper identifies CD5L as a component of circulatory IgM, showing it forms a complex with J-chain-containing pentamers and affects IgM receptor binding.