Lyonna F. Parise

Molecular dissection of protein complexes isolated from sections of human brain

The paper develops a method to study endogenous protein complexes in brain tissue and finds mGluR2/3 heterodimers are abundant in specific human brain regions and associated with depression.

Transcriptional Profiles of Antidepressant Resistance Across the Corticolimbic Pathway of Chronically Stressed Mice

This study identifies transcriptional differences in mice with antidepressant resistance using RNA sequencing of brain regions after stress and drug treatment.

A shared transcriptional network in the nucleus accumbens supports resilience to chronic stress across sex.

The paper identifies a shared transcriptional network in the nucleus accumbens that supports stress resilience in both sexes and shows causal effects of hub genes.

Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression

This study identifies astrocyte-derived extracellular matrix proteins, particularly SPARC, as regulators of synapse remodeling in stress-induced depression.

Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene Htra1

The paper identifies sex-specific regulation of stress susceptibility by the astrocytic gene Htra1 in mice and humans, showing differential effects on neuronal signaling and ECM integrity.

Male and female variability in response to chronic stress and morphine in C57BL/6J, DBA/2J, and their BXD progeny

The paper investigates genetic and sex differences in stress and morphine responses across mouse strains and their progeny, finding genetic influences on stress vulnerability and morphine sensitivity.

Viral-mediated expression of Erk2 in the nucleus accumbens regulates responses to rewarding and aversive stimuli.

This study shows that manipulating ERK2 levels in the nucleus accumbens of rats alters behaviors related to reward and aversion, with overexpression increasing depression-like and cocaine sensitivity behaviors, and knockdown reducing them.

Sex-specific blood-brain barrier alterations and vascular biomarkers underlie chronic stress responses in mice and human depression.

History of winning and hierarchy landscape influence stress susceptibility in mice

The paper shows that social rank and history of winning influence stress susceptibility in mice, with dominance conferring resilience and subordination increasing susceptibility.

Zfp189 Mediates Stress Resilience Through a CREB-Regulated Transcriptional Network in Prefrontal Cortex

The paper identifies Zfp189 as a key driver of a transcriptional network promoting stress resilience in prefrontal cortex neurons through CREB regulation.