Zhongzhou Yang

Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

The paper uses single-cell multi-omics to study early cardiac lineage specification in mouse embryos, identifying key transcription factors and regulatory networks.

Angiocrine FSTL1 insufficiency leads to atrial and vein wall fibrosis via SMAD3 activation

This study shows that loss of endothelial FSTL1 causes atrial and vein wall fibrosis through SMAD3 activation, leading to heart failure.

The long noncoding RNA Hand2as orchestrates heart development through regulation of precise expression of HAND2

This study identifies Hand2as as a key lncRNA regulating HAND2 expression in heart development through single-cell RNA sequencing and knockout models, leading to congenital defects and perinatal lethality.