Kari K. Alitalo

Redirecting full-length FLT1 expression towards its soluble isoform promotes postischemic angiogenesis

The paper shows that promoting soluble FLT1 over full-length FLT1 enhances postischemic angiogenesis by modulating gene isoform expression through APA.

Targeting de novo cholesterol synthesis in rhabdomyosarcoma induces cell cycle arrest and triggers apoptosis through ER stress-mediated pathways

This study shows that inhibiting cholesterol biosynthesis in rhabdomyosarcoma cells induces ER stress, apoptosis, and cell cycle arrest, suggesting a new therapeutic strategy for this aggressive cancer.

Specialized mesenteric lymphatic capillaries by-pass the mesenteric lymph node chain to transport peritoneal antigens directly into mediastinal lymph nodes.

The paper identifies a specialized mesenteric lymphatic capillary network that bypasses mesenteric lymph nodes to directly transport peritoneal antigens into mediastinal lymph nodes.

Endothelial TIE1 restricts angiogenic sprouting to coordinate vein assembly in synergy with its homologue TIE2

This study investigates the role of TIE1 and its interaction with TIE2 in venous development, finding that TIE1 restricts angiogenic sprouting to coordinate vein formation.

VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes

This study shows that VEGF-C overexpression enhances brain fluid drainage, provides neuroprotection, and improves stroke outcomes in mice.

The blood vasculature instructs lymphatics patterning in a SOX7-dependent manner

This study identifies SOX7 as a transcription factor in blood vascular endothelial cells that represses Vegfc expression, influencing lymphatic vessel patterning in mice.