Author

Omar I. Avila

Broad InstituteORCID 0000-0002-3853-9939Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Kathleen B. YatesiD· 2 shared Robert T. MangusoiD· 2 shared Aidan Cruickshank· 1 shared Alexánder RojasiD· 1 shared Andrew Mark BrunneriD· 1 shared Ashwin V. KammulaiD· 1 shared Audrey J. MuscatoiD· 1 shared Celeste Nobrega· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Kathleen B. YatesORCID

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2 papers

Recent·Most cited

Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis

Jooho Chung, Mounica Vallurupalli, Sarah Noel, Gail Schor, YuhJong Liu, Celeste Nobrega, Jonathan Perera, Ewa Wrona, Margaret Hu, Yunkang Lin, David Wei Wu, Maria Saberi, Ilario Scapozza, Aidan Cruickshank, Elliot C. Woods, , Robert T. Manguso

The paper identifies CD43 as a glyco-immune checkpoint that inhibits human macrophage phagocytosis, showing that O-linked glycosylation and sialylation pathways regulate this process in AML.

bioRxiv · May 5, 2025 · PreprintCancer Biology

In vivo generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance

Kepler S. Mears, Kyrellos E. Ibrahim, Peter M. Allen, Jordan M. Chinai, Omar I. Avila, Audrey J. Muscato, Sarah Kate Lane-Reticker, Alexánder Rojas, Nelson H. Knudsen, Chun‐Cheih Chao, Kathleen B. Yates, Robert T. Manguso

This study develops lentiviral vectors with improved specificity and reduced immune clearance for in vivo CAR T cell generation, showing efficacy in a preclinical model.

bioRxiv · Apr 23, 2025 · PreprintBioengineering