The paper investigates the role of MKK3 in adipose tissue during obesity, finding that its activation protects against insulin resistance by enhancing p38-beta signaling.

Advanced Science · Oct 28, 2026Peer-reviewedMolecular Biology

A hypothalamus-liver-skeletal muscle axis controlled by JNK1 and FGF21 mediates olanzapine-induced insulin resistance in an intraperitoneal treatment in male mice

Vítor Ferreira, Cintia Folgueira, Ana B. Hitos, Ángela Montes-San Lorenzo, Ánxela Estévez‐Salguero, Begoña Porteiro, Roger J. Davis, Miguel López, Guadalupe Sabio, Patricia Rada, Ángela M. Valverde

This study shows that intraperitoneal olanzapine treatment in male mice causes insulin resistance via a hypothalamus-liver-skeletal muscle axis involving JNK1 and FGF21, with PTP1B deficiency offering protection.

Redox Biology · Jul 2, 2026Peer-reviewedPhysiology

Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity

Tigist Y. Tamir, Shreya Chaudhary, Annie X Li, S. E. Trojan, Cameron T. Flower, Paula Vo, Yufei Cui, Jeffrey C Davis, Rachit S Mukkamala, Francesca N Venditti, Alissandra L. Hillis, Alex Toker, Matthew G. Vander Heiden, Jessica B. Spinelli, Norman J. Kennedy, , Forest M. White

This study identifies sex-specific metabolic reprogramming in obesity by analyzing phosphorylation sites on metabolic enzymes and their functional impact.

Molecular Cell · Aug 29, 2024Peer-reviewedBiochemistry

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

Abigail O. Smith, Julie A. Jonassen, Kenley M. Preval, Roger J. Davis, Gregory J. Pazour

This study shows that JNK signaling promotes cyst growth in ADPKD by enhancing cell proliferation and that inhibiting JNK reduces cyst severity.

PLoS Genetics · Dec 28, 2021Peer-reviewedGenetics