Nicholas J. Bray

drugMR: A multi-omics pipeline for genetically anchored drug-target discovery

drugMR uses multi-omics data to identify potential drug targets and adverse effects by integrating GWAS and pQTL statistics with various statistical methods.

Polygenic effects on cortical size and ADHD converge on a mid-gestational progenitor-to-neuron transition programme

The paper identifies a mid-gestational molecular mechanism linking cortical size and ADHD through genetic and single-cell RNA sequencing analyses.

Developmental, neuroanatomical and cellular expression of genes causing dystonia

The paper examines the expression patterns of dystonia-causing genes across developmental stages and brain regions to identify key areas and cell types for disease modeling and therapy.

The relationship between shared and differentiating genetic liability for schizophrenia and bipolar disorder and cognition and educational attainment in the UK Biobank

This paper investigates how genetic liabilities shared and differentiating between schizophrenia and bipolar disorder relate to cognition and educational attainment using UK Biobank data.

Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia

The paper investigates genetic risk for schizophrenia by analyzing gene expression and regulatory elements in developing ganglionic eminence neurons.

Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain

The paper constructs a cross-ancestry, cell-type-informed gene regulatory atlas of the developing human brain, identifying genetic regulation and linking it to neuropsychiatric disorders.

Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders

The paper maps open chromatin regions in prenatal human frontal cortex and shows enrichment of SNP heritability for neuropsychiatric disorders within these regions.

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.

The paper develops a novel epigenetic clock for fetal brain development to predict prenatal age in iPSCs and derived neurons, showing they remain epigenetically fetal despite differentiation.

Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex

This study uses long-read RNA sequencing to analyze isoform diversity in human and mouse cerebral cortex, revealing widespread alternative splicing and novel transcripts.

A Transcriptome Wide Association Study implicates specific pre- and post-synaptic abnormalities in Schizophrenia

This study performs a transcriptome-wide association study to link schizophrenia risk variants to gene expression in the dorsolateral prefrontal cortex, identifying 89 genes associated with pre- and post-synaptic abnormalities.

Novel Insight into the Aetiology of Autism Spectrum Disorder Gained by Integrating Expression Data with Genome-wide Association Statistics

This study integrates ASD GWAS summary statistics with gene expression data to identify differentially expressed genes in ASD and estimate heritability explained by predicted expression.

Psychiatric risk gene NT5C2 regulates protein translation in human neural progenitor cells

This study identifies NT5C2 as a psychiatric risk gene, showing its role in protein translation and AMPK signaling in neural progenitor cells and Drosophila melanogaster.

Sex differences in gene expression in the human fetal brain

The paper analyzes RNA sequencing data from human fetal brains to identify sex-biased gene expression, finding differences in 2558 autosomal and 155 X-chromosome genes, with implications for neurodevelopmental disorders.

5-Hydroxymethylcytosine Is Highly Dynamic Across Human Fetal Brain Development

The paper quantifies 5-hydroxymethylcytosine (5hmC) changes across 71 human fetal brain samples and identifies sex differences and genetic associations.