Susan L. Moir

Neutralization activity in chronic HIV infection is characterized by a distinct programming of follicular helper CD4 T cells

The paper identifies distinct follicular helper CD4 T cell programming in HIV-positive individuals who produce broadly neutralizing antibodies, linking it to improved B cell follicle architecture and reduced suppressor cells.

Dynamic Antigen Expression and Intrinsic CTL Resistance in HIV Reservoir Clones

This study characterizes HIV reservoir clones and shows they can be culled by sustained CTL pressure, with some displaying intrinsic resistance linked to low oxidative stress.

Super-silencers are crucial for development and carcinogenesis in B cells.

The paper identifies super-silencers in B cells, showing their role in development and their conversion to super-enhancers in lymphoma, with implications for carcinogenesis.

Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome

This study identifies de novo LYN variants causing constitutive Lyn kinase activation, leading to neutrophilic vasculitis and liver fibrosis, and shows therapeutic response to Src kinase inhibitors.